Clinical Trials & Research News

Naloxone Vending Machines Prevented Almost 1,000 Deaths

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Based on data from the CDC, since 1999, there have been nearly one million overdose-related deaths. In 2020, the United States reported 91,799 overdose deaths, a 31% increase from the previous year....

Merck and Moderna Find Success with Cancer Vaccine Clinical Trial

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Pharmaceutical companies Merck & Co and Moderna Inc announced positive clinical trial results for their investigational melanoma vaccine candidate last week. The personalized cancer treatment that...

Oral Butyrate Supplementation Treats Pediatric Obesity

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According to the CDC, 20% of children and adolescents in the United States deal with pediatric obesity. Obesity is linked with high blood pressure, high cholesterol, type 2 diabetes, joint problems,...

Comparing Buprenorphine and Methadone for OUD During Pregnancy

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Data from the CDC suggests that 75% of overdoses in the United States involve opioids. It is abundantly clear to healthcare professionals that the rates of opioid use disorder (OUD) are rising —...

FDA Approves $3.5 Million per Dose Hemophilia B Gene Therapy

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Last week, the FDA’s Center for Biologics Evaluation and Research announced the approval of Hemgenix, an adeno-associated virus vector-based gene therapy for adults with hemophilia B (congenital...

Wound Infiltration May Reduce Pain Following Cesarean Delivery

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In an article published in JAMA Network Open by Gali Garmi, MD, and his colleagues state that cesarean delivery — commonly referred to as a C-section — is the most common abdominal surgery...

FDA Clears Clinical Trials on Investigational New Drug for ALS

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Amyotrophic lateral sclerosis, ALS, is a life-threatening neurodegenerative disease that can lead to paralysis and death. Over 5,000 individuals in the United States are diagnosed with ALS each year,...

A Single Dose of Psilocybin Can Reduce MADRS Score

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BMC Psychiatry states that up to one-third of patients with major depressive disorder become resistant to treatment, otherwise known as treatment-resistant depression. In recent years, psilocybin and...

Study Finds Increased Prevalence of Nonpharmacological Pain Treatment

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Following a publication earlier this year that analyzed patterns in prescribing nonopioid pain medication, JAMA Network Open published an article on November 7, 2022, which compared trends in...

How Mesenchymal Stem Cells May Reduce the Need for Antirejection Drugs

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In a recent press release, Cynata Therapeutics, a biotechnology company, announced a partnership with Leiden University Medical Center (LUMC) to explore how mesenchymal stem cells may reduce the need...

FDA Approves Investigational Drug Application for Bi-Functional Fusion Protein

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In a recent announcement, the Simcere Pharmaceutical Group — a global pharmaceutical company with origins in China — revealed that the FDA approved its investigational new drug application...

RSV Cases Flood Children’s Hospitals as Pfizer Announces Promising Vaccine

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After producing strong clinical trial results for its respiratory syncytial virus (RSV) vaccine, Pfizer says it is ending enrollment in its study and preparing to submit for FDA approval. The Phase 3...

Motivational Interventions May Improve SUD Recovery

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On October 21, 2022, JAMA Network Open published the results of a randomized clinical trial on the effects of emergency room motivational interventions on substance use disorders (SUD). Using a cohort...

Nearly 13% of Oral Anticancer Prescriptions Are Not Received

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The financial burden associated with cancer treatment and recovery is significant. Many patients struggle to obtain medicines and continued care. According to a recent study published in JAMA Network...

US Department of Defense Grants $2.97 Million to Treventis

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According to a press statement released on October 18, 2022, the Treventis Corporation, a biotechnology company, was granted $2.97 million to research and develop an anti-tau misfolding drug. The press...

Etripamil Phase III Clinical Trials Are Successful

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Milestone Pharmaceuticals recently announced positive test results from a phase III clinical trial of etripamil, a calcium channel blocker to treat paroxysmal supraventricular tachycardia (PSVT). PSVT...

Orexo Pharmaceuticals Announces Phase I Clinical Study Data

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Months after announcing the development of a nasal epinephrine rescue medication, Orexo Pharmaceuticals announced positive phase I clinical trial data on the drug — called OX640. Epinephrine is a...

How Excluding Disabled Populations from Clinical Trials Impacts Care

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Using data from ClinicalTrials.gov, researchers collected data on eligibility criteria from approximately 100 clinical research protocols. Of the 97 interventional studies, 14 focused on dementia, 24...

J&J Ulcerative Colitis Clinical Trial Produces High Rate of Remission

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Johnson & Johnson announced positive results from the VEGA Phase 2 clinical trial that paired the monoclonal antibody Tremfya (guselkumab) and the immunosuppressive drug Simponi (golimumab). The...

COVID-19 Vaccination Alters Menstrual Cycle Length

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As the COVID-19 pandemic continues and vaccinations continue to be advanced, many patients are concerned about vaccine side effects. Multiple sources have perpetuated the misconception that COVID-19...